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Furthermore, a randomized controlled trial in patients with chronic hepatitis C demonstrated that combination therapy with UDCA and glycyrrhizin produced significantly greater reductions in serum aminotransferases and -glutamyl transpeptidase (-GTP) compared to glycyrrhizin alone, without affecting HCV RNA levels, indicating a hepatoprotective rather than antiviral synergy (Tsubota et al., 1999)

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Cryer PE, Axelrod L, Grossman AB, Heller SR, Montori VM, Seaquist ER, et al

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Additionally, bioinformatics relies on computational tools to analyze biological data, while ML can optimize the generalization ability of ML algorithms, reducing prediction bias caused by overly simplified algorithms (Sarvepalli and Vadarevu, 2025)